Injuries, penalties stall the Buffalo Bills in a 25-20 loss to the Jacksonville Jaguars

LONDON, UK. (WKBW) — Behind a plethora of key injuries and a penalty-ridden game, the Buffalo Bills fell 25-20 to the Jacksonville Jaguars at Tottenham Hotspur Stadium in London, UK.

Both teams started with punts on their opening drives, but the Jaguars struck first on their next drive. Trevor Lawrence connected with former Buffalo Bill Zay Jones for a six-yard touchdown (two-point conversion after Ed Oliver's penalty). However, the major storyline out of that drive was the knee injury sustained by Bills linebacker Matt Milano.

Milano was ruled out shortly after being helped off the field. Daquan Jones was also banged up on that drive with a pectoral injury and was ruled 'doubtful' to return.

After the game, Bills head coach Sean McDermott addressed Milano's injury and said "I know it's not looking good right now, but I don't know any details beyond that at this point." McDermott also addressed Jones' injury and said "Also not looking good at this point." You can watch McDermott's full press conference in the video player above.

READ MORE: What now? Matt Milano's injury piles more adversity and uncertainty on the Buffalo Bills defense

According to a report from Ian Rapoport of the NFL Network, Milano suffered a fractured leg and is feared to have suffered a season-ending knee injury. "They are checking on the ACL. MRI coming, but missing the rest of the season is likely," Rapoport said in a tweet.

After Jacksonville's third drive of the game ended in a field goal, the ensuing Buffalo drive would result in a punt.

Trailing 11-0, the Bills last offensive drive before halftime finally ended in points. Josh Allen and Stefon Diggs linked up for a 15-yard touchdown to spark what was an otherwise stalled offense in the first half. Jacksonville would try to add a field goal before the halftime break, but deep in the red zone Bills defensive end AJ Epenesa brought heavy pressure into the backfield and forced a Lawrence fumble that he also recovered.

Buffalo trailed 11-7 heading into halftime.

Out of the break, both offenses struggled to add points. The Bills offense had some big plays but ultimately went scoreless in the third, as did the Jaguars, and the score remained 11-7 heading into the fourth quarter.

Two plays into the fourth, after Epenesa's third pass deflection of the game, Ed Oliver would force the strip-sack on Trevor Lawrence in the red zone and the ball was recovered by Tyrel Dodson.

However, this Bills offense continued to struggle as penalties stalled drives. On 3rd and 15, Allen took a deep shot to Diggs, but that 50/50 jump ball was intercepted by Darius Williams.

Jacksonville took their ensuing drive 93 yards in 10 plays resulting in a Travis Etienne touchdown.

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So trailing 18-7, Buffalo drove down the field in nine plays for 75 yards which ended in an Allen to Gabe Davis touchdown that technically happened twice as Davis was called for offensive pass interference on the first attempt. Buffalo's two-point conversion was no good. The score remained 18-13.

Needing a big stop on the ensuing Jags drive. On third down and four, Lawrence floated a perfect pass to Calvin Ridley to extend the drive. McDermott took his final timeout after the next play and then Etienne took the next run 35 yards for a touchdown.

Just when you thought a 25-13 deficit was how this game would end, Allen and the offense pulled off a four-play, 75-yard drive in large part due to a 43-yard pass to Deonte Harty. Allen called his own number and scored on a three-yard run to make it a 25-20 deficit.

Buffalo then attempted an onside kick that had a chance to be recovered, but instead, it landed out of bounds.

READ MORE: Too little, too late; Buffalo Bills offense sputters in loss to Jaguars

Their defense forced a punt. However, with only 22 seconds on the clock, Allen would connect with Diggs over the middle who tried lateraling the ball back to James Cook which resulted in a fumble that was recovered by the Jaguars.

25-20 Jacksonville was the final. Buffalo returns home to host the New York Giants next week on Sunday Night Football.